It is now 3 decades that we have global intensive research on converting lignocelluloses to different value-added products such as ethanol and butanol. There are now hundreds of thousands of publications and patents on these subjects, but still, we don't have any large scale commercial plant. One of the major problems of this subject is the recalcitrance and complexity of the biomass, which make it unaccessible to enzymes and microorganisms. The nature designed this material to stay long, but we want to degrade it quickly. We are tackling with this problem in 15 years now, and still, a long way to go! We have recently had "Biomass Recalcitrance" as a PhD course, and know that the understanding of this complexity need much more research!
(Our current understanding of the cell wall structure. The pictures were adopted from a very good book on this subject)